Screening

The Quest for new Bioactives

Our screening partners in life science engage in the fields of infectious diseases, neurodegenerative or inflammatory diseases as well as regenerative medicine or the emergence and treatment of cancer, to name just a few. Access to a wide range of methodologies, like high-throughput screenings, macromolecular crystallography or in-silico modelling is provided by our partners.

The Molecule Archive offers different solutions to meet the needs and requirements of your screening setup and testing system regarding the size of the selection, the format, the physical state of the compounds and the target specificities.

Library Size

  • Small-sized libaries (< 100 compounds) or single compounds
  • Medium-sized libraries (> 100 compounds)
  • Entire libary of all 12,000 compounds

 

Library Format

  • Single tubes e.g. Eppendorf tubes
  • SBS-standard microplates in 96- and 384- formats
  • Special formats e.g. ECHO qualified microplates
  • Assay ready plates

Physical State

  • 10 mM DMSO solutions (also higher if needed)
  • Dry substance

Compound Selection

  • Diversity-based (clustering)
  • Similarity-based (2D/3D similarity)
  • Virtual Screening

Our Life Science Screening Network

Deutschlandkarte
KIT Karlsruhe, Institute of Functional Interfaces​:
  • Ute Schepers:
    3D Tissue Engineering, Organ-targeted Drug Delivery
KIT Karlsruhe, Institute for Biological and Chemical Interfaces - Biologial Information Processing:
  • Andrew Cato:
    Androgen Receptor Signaling
  • Ravindra Peravali:
    Zebrafish Morphological/Behavioral Screenings
KIT Karlsruhe, Institute for Chemical and Biological Interfaces - Functional Molecular Systems:
  • Pavel Levkin:
    Diverse Screenings on Droplet Microarrays


Go To

University Hospital Freiburg
  • Bernd Fiebich:
    Neuroinflammation and Neurodegeneration


Go To

University of Heidelberg
  • Annika Guse:
    Mechanisms of Endosymbiosis, Phagocytosis, Immunity, Metabolism and Adaption to Environment
  • Thomas Holstein:
    Stem Cell Biology and Regeneration
  • Steffen Lemke:
    Molecular Mechanisms of Intercellular Communication
  • Suat Özbek:
    Evolution of Extracellular Matrix and Signaling Molecules


Go To

Leibniz Lung Center Borstel
  • Norbert Reiling: Identification of Anti-Mycobacterial Pathways and Therapeutics
  • Ulrich Schaible: Characterization of Interactions between M. tuberculosis and Host Cells

Go To
Technical University Darmstadt, Department of Chemistry
  • Katja Schmitz:
    Identification of Chemokine-Receptor Ligands


Go To

Max Planck Institute of Molecular Cell Biology and Genetics Dresden (MPI-CBG)
  • Anna Dubrovska
    Cancer Stem Cell Biology and Epigenetics
  • Rico Barsacchi:
    High-Throughput Assay Development

 

Go To

Medical School Hannover, Helmholtz Centre for Infection Research (HZI)
  • Thomas Pietschmann:
    Antiviral Drug Discovery and Development


Go To

Research Center Jülich, Institute of Neuroscience and Medicine
  • Paolo Carloni and Giuliana Rossetti:
    Computational Design of Neuroactive Drugs


Go To

University of Konstanz
  • Screening Center Konstanz


Go To

University of Heidelberg, Medical Faculty Mannheim
  • Jonathan Sleeman:
    Regulation of Metastasis and Development of Anti-Cancer Therapies


Go To

LMU Munich
  • Oliver Keppler:
    Pathology of HIV Infections and Development of Therapies
  • Daniel Merk:
    Medicinal Chemistry of Nuclear Receptor Ligands


Go To

University of Kaiserslautern
  • Jörg Fahrer:
    DNA Damage Response and DNA Repair Pathways, Mechanisms of Colorectal Cancer


Go To

University of Greifswald
  • Ulrike Garscha:
    Anti-Inflammatory Properties/ Lipid Mediator Biosynthesis in Primary and Cancer Cells

    Go To
University of Mainz
  • Tanja Schirmeister:
    Medicinal Chemistry of Human, Viral and Parasitic Proteases and RNA Methyltransferase


Go To

University of Bonn
  • Christa Müller:
    Medicinal Chemistry of Purinergic Receptors, GPCRs and Ectonucleotidases


Go To

Helmholtz-Zentrum Berlin, Department of Photon Science
  • Manfred Weiss:
    Macromolecular Crystallography of Proteins and Protein-Ligand-Complexes
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
  • Jens von Kries:
    High-Throughput Screening Platform with variuos Assays

Go To

Meet our Partners in Life Sciences

Germany

Wolfgang
Fecke
EU-OPENSCREEN
Institution
Life Science
Category
Screening, medicinal chemistry and open access database
Type
HTS and FBDD
Throughput
Berlin, more than 20 affiliated sites in nine countries
Location
Manfred Weiss
Helmholtz-Zentrum Berlin für Materialien und Energie, Department of Photon Science
Institution
Life Science
Category
Research Group
Type
Small-scale single assays
Throughput
Berlin
Location
Jens von Kries
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Screening Unit
Instituiton
Life Science
Category
Screening Facility
Type
HTS
Throughput
Berlin
Location
Christa Müller
Pharmazentrum Bonn, Department of Pharmaceutical & Medicinal Chemistry, Pharmaceutical Institute
Institution
Life Science
Category
Research group
Type
HTS 
Throughput
Bonn
Location
Ulrich Schaible
Leibniz Lung Center Borstel, Research Area Infections

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Borstel
Location
Norbert Reiling
Leibniz Lung Center Borstel, Research Area Infections

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Borstel
Location
Katja Schmitz
Technical University Darmstadt, Department of Chemistry

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Darmstadt
Location
Sonja Sievers
Max Planck Institute of Molecular Physiology, Compound Management and Screening (COMAS)

Institution

Life Science
Category
Screening Facility
Type
 HTS
Throughput
Dortmund
Location
Anna Dubrovska

Dresden University of Technology

Institution

Life Science
Category

Research Group

Type

Small-scale single assays

Throughput

Dresden

Location
Rico Barsacchi

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Technology Development Studio (TDS)

Institution

Life Science
Category
Screening Facility
Type
HTS
Throughput
Dresden
Location
Bernd Fiebich

University Hospital Freiburg, Klinik für Psychiatrie und Psychotherapie

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Freiburg
Location
Ulrike Garscha

University of Greifswald, Institute of Pharmacy

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Greifswald
Location
Thomas Pietschmann
Medical School Hannover and Helmholtz Centre for Infection Research (HZI)

Institution

Life Science
Category
Antiviral drug discovery and development
Type
HTS
Throughput
Hannover
Location
Steffen Lemke
University of Heidelberg, Centre for Organismal Studies

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Heidelberg
Location
Suat Özbek
University of Heidelberg, Centre for Organismal Studies

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Heidelberg
Location
Thomas Holstein
University of Heidelberg, Centre for Organismal Studies

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Heidelberg
Location
Annika Guse
University of Heidelberg, Centre for Organismal Studies

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Heidelberg
Location
Paolo Carloni and Giulia Rossetti
Forschungszentrum Jülich

Institution

Life Science
Category
Research group
Type
Virtual Screening
Throughput
Jülich
Location
Jörg Fahrer
University of Kaiserslautern, Division of Food Chemistry and Toxicology

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Kaiserslautern
Location
Ute Schepers
KIT Karlsruhe, Institute of Functional Interfaces
Partner Name
Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Karlsruhe
Location
Andrew Cato
KIT Karlsruhe, Insitute of Biological and Chemical Systems – Biological Information Processing

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Karlsruhe
Location
Pavel Levkin
KIT Karlsruhe, Institute of Biological and Chemical Systems – Functional Molecular Systems

Institution

Life Science
Category
Research group
Type
HTS
Throughput
Karlsruhe
Location
Ravindra Peravali
KIT Karlsruhe, Insitute of Biological and Chemical Systems – Biological Information Processing, European Zebrafish Ressource Center (EZRC)

Institution

Life Science
Category
Screening Center
Type
large-scale screening
Throughput
Karlsruhe
Location
Thomas Mayer
Screening Center Konstanz

Institution

Life Science
Category
Screening Facility
Type
HTS
Throughput
Konstanz
Location
Tanja Schirmeister
University of Mainz, Institute of Pharmacy and Biomedical Sciences

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Mainz
Location
Jonathan Sleeman
Medical Faculty Mannheim, Centrum für Biomedizin und Medizintechnik Mannheim (CBTM)/ KIT Karlsruhe IBCS-BIP

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Mannheim/Karlsruhe
Location
Oliver Keppler
LMU Munich, Gene Center & Max von Pettenkofer-Institute for Hygiene and Mediccal Microbiology, Chair of Virology

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
München
Location
Daniel Merk
LMU Munich, Department of Pharmacy

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
München
Location

International

Jennifer Keiser
Swiss Tropical and Public Health Institute (TPH)

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Basel
Location
Johannes Zuegg
University of Queensland, Community for OpenAntimicrobial Drug Discovery (CO-ADD)

Institution

Life Science
Category
Screening Facility
Type
HTS
Throughput
Brisbane
Location
Steven Cobb
University of Durham, Department of Chemistry, Wolfson Research Institute for Health and Wellbeing

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Durham
Location
Kelly Chibale

University of Cape Town, Drug Discovery and Development Centre (H3D)

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Cape Town
Location
Luca Grumolato
University of Rouen, Molecular Oncology Group

Institution

Life Science
Category
Research group
Type
Small-scale single assays
Throughput
Rouen
Location

Become a Life Science Screening Partner

You have become interested and want to participate as a screening partner and get compounds?

Feel free to contact us via our homepage or directly through mail or by phone. For more information, have a look under Contact.

Leave us a message!

    Topic




    Or choose one of these ways to contact us:

    compound-platform@ioc.kit.edu

    +49 721 608 23087

    Karlsruhe Institute of Technology (KIT)
    Institute of Biological and Chemical Systems (IBCS)
    Compound Platform (ComPlat)
    Hermann-von-Helmholtz-Platz 1
    Building 319, room 405-443
    76344 Eggenstein-Leopoldshafen
    Germany