Screening
The Quest for new Bioactives
Our screening partners in life science engage in the fields of infectious diseases, neurodegenerative or inflammatory diseases as well as regenerative medicine or the emergence and treatment of cancer, to name just a few. Access to a wide range of methodologies, like high-throughput screenings, macromolecular crystallography or in-silico modelling is provided by our partners.
The Molecule Archive offers different solutions to meet the needs and requirements of your screening setup and testing system regarding the size of the selection, the format, the physical state of the compounds and the target specificities.
Library Size
- Small-sized libaries (< 100 compounds) or single compounds
- Medium-sized libraries (> 100 compounds)
- Entire libary of all 13,000 compounds
Library Format
- Single tubes e.g. Eppendorf tubes
- SBS-standard microplates in 96- and 384- formats
- Special formats e.g. ECHO qualified microplates
- Assay ready plates
Physical State
- 10 mM DMSO solutions (also higher if needed)
- Dry substance
Compound Selection
- Diversity-based (clustering)
- Similarity-based (2D/3D similarity)
- Virtual Screening
Our Life Science Screening Network
KIT Karlsruhe, Institute of Functional Interfaces
- Ute Schepers:
3D Tissue Engineering, Organ-targeted Drug Delivery
KIT Karlsruhe, Institute for Biological and Chemical Interfaces - Biologial Information Processing:
- Andrew Cato:
Androgen Receptor Signaling - Ravindra Peravali:
Zebrafish Morphological/Behavioral Screenings
KIT Karlsruhe, Institute for Chemical and Biological Interfaces - Functional Molecular Systems:
- Gary Davidson:
Cellular Communication via Wnt-Signaling
- Pavel Levkin:
Diverse Screenings on Droplet Microarrays - Veronique Orian-Rousseau
Molecular Mechanisms of Action of Cell Adhesion Molecule CD44
University Hospital Freiburg
- Bernd Fiebich:
Neuroinflammation and Neurodegeneration - Manfred Jung
Chemical Epigenetics, Assay Development and Design of Inhibitors of Histone-modifying enzymes
European Molecular Biology Laboratory (EMBL)
- Chemical Biology Core Facility
University of Heidelberg
- Thomas Holstein:
Stem Cell Biology and Regeneration - Steffen Lemke:
Molecular Mechanisms of Intercellular Communication - Suat Özbek:
Evolution of Extracellular Matrix and Signaling Molecules
Leibniz Lung Center Borstel
- Norbert Reiling: Identification of Anti-Mycobacterial Pathways and Therapeutics
- Ulrich Schaible: Characterization of Interactions between M. tuberculosis and Host Cells
Go To
Technical University Darmstadt, Department of Chemistry
- Katja Schmitz:
Identification of Chemokine-Receptor Ligands
Max Planck Institute of Molecular Cell Biology and Genetics Dresden (MPI-CBG)
- Anna Dubrovska
Cancer Stem Cell Biology and Epigenetics - Rico Barsacchi:
High-Throughput Assay Development
University of Göttingen, Institute of Forest Zoology and Forest Conservation
- Martin Gabriel:
Development of efficient and near-natural and control methods for sustainable forest-management
Ruhr University Bochum, Faculty of Chemistry and Biochemistry
- Axel Rosenhahn:
Dynamics of surface colonization by microorganisms
Medical School Hannover, Helmholtz Centre for Infection Research (HZI)
- Thomas Pietschmann:
Antiviral Drug Discovery and Development
University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology (ZMNH)
- Meliha Karsak:
Intracellular Interactions and Signaling of the Cannabinoid Receptor
German Electron Synchrotron (DESY), Center for Free-electron Laser Science
- Alke Meents
X-ray Crystallography of Ligand-Receptor Complexes
Research Center Jülich, Institute of Neuroscience and Medicine
- Paolo Carloni and Giuliana Rossetti:
Computational Design of Neuroactive Drugs
University of Konstanz
- Martin Scheffner
Biochemical and physiological aspects of the Ubiquitin-Conjugation System - Screening Center Konstanz
University of Heidelberg, Medical Faculty Mannheim
- Jonathan Sleeman:
Regulation of Metastasis and Development of Anti-Cancer Therapies
LMU Munich
- Annika Guse:
Zelluläre und Organismische Systeme
Oliver Keppler:
Pathology of HIV Infections and Development of Therapies - Daniel Merk:
Medicinal Chemistry of Nuclear Receptor Ligands
University of Erlangen-Nürnberg
- Jutta Eichler: Design of novel antivirals based on viral binding sites and host cell receptors.
University of Kaiserslautern
- Jörg Fahrer:
DNA Damage Response and DNA Repair Pathways, Mechanisms of Colorectal Cancer
University of Greifswald
- Mihaela Delcea
Inhibition of BCL11B Homodimerization - Ulrike Garscha:
Anti-Inflammatory Properties/ Lipid Mediator Biosynthesis in Primary and Cancer Cells
University of Mainz
- Tanja Schirmeister:
Medicinal Chemistry of Human, Viral and Parasitic Proteases and RNA Methyltransferase
University of Bonn
- Christa Müller:
Medicinal Chemistry of Purinergic Receptors, GPCRs and Ectonucleotidases
University of Marburg
- Peter Kolb: Chemoinformaticsm, Molecular Dynamics Simulations, Molecular Machine Learning
EU-Openscreen
- Mads Clausen
Helmholtz-Zentrum Berlin, Department of Photon Science
- Manfred Weiss:
Macromolecular Crystallography of Proteins and Protein-Ligand-Complexes
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
- Jens von Kries:
High-Throughput Screening Platform with variuos Assays
Universitätsklinikum Jena, Institute of Human Genetics
- Aria Baniahmad:
Mechanisms of Therapy Resistance Formation in Prostate Cancer Cells
Meet our Partners in Life Sciences
Germany
Mads
Clausen
Berlin & more than 20 affiliated sites in nine countries
Manfred
Weiss
Jens
von Kries
Axel
Rosenhahn
Ruhr University of Bochum, Faculty of Chemistry and Biochemistry
Analytical Chemistry & Life Science
Research Group
Small-scale single assays
Bochum
Christa
Müller
Ulrich
Schaible
Institution
Norbert
Reiling
Institution
Katja
Schmitz
Institution
Sonja
Sievers
Institution
High-Throughput Screening
Anna
Dubrovska
Dresden University of Technology
Institution
Research Group
Small-scale single assays
Dresden
MPI-CBG
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Technology Development Studio (TDS)
Institution
Jutta
Eichler
University of Erlangen-Nürnberg, Department Chemistry and Pharmacy
Institution
Research Group
Pooled (high-throughput) Screening
Erlangen
Bernd
Fiebich
University Hospital Freiburg, Klinik für Psychiatrie und Psychotherapie
Institution
Manfred
Jung
University of Freiburg, Institute of Pharmaceutical Sciences
Institution
Mihaela
Delcea
University of Greifswald, Institute of Biochemistry
Institution
Greifswald
Ulrike
Garscha
University of Greifswald, Institute of Pharmacy
Institution
Martin
Gabriel
University of Göttingen, Institute of Forest Zoology and Forest Conservation
Institution
Climate Research
Research Group
Small-scale single assays
Göttingen
Meliha
Karsak
University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology (ZMNH)
Institution
Research Group
Small-scale single assays
Hamburg
German Electron Synchrotron (DESY)
German Electron Synchrotron (DESY), Center for Free-electron Laser Science (CFEL)
Institution
Research Group
High-Throughput Screening
Hamburg
Thomas
Pietschmann
Institution
High-Throughput Screening
EMBL
Chemical Biology Core Facility
Institution
Screening Center
High-Throughput Screening
Heidelberg
Thomas
Holstein
Institution
Steffen
Lemke
Institution
Suat
Özbek
Institution
Aria
Baniahmad
University Hospital of Jena, Institute of Human Genetics
Institution
Jena
Paolo Carloni and Giulia Rossetti
Institution
Jörg
Fahrer
Institution
Andrew
Cato
Institution
Gary
Davidson
KIT Karlsruhe, Institute of Biological and Chemical Systems – Functional Molecular Systems
Institution
Pavel
Levkin
Institution
High-Throughput Screening
Veronique
Orian-Rousseau
Institution
Small-scale single assays
Ute
Schepers
Ravindra
Peravali
Institution
Thomas
Mayer
Institution
Martin
Scheffner
University of Konstanz, Department of Biology
Institution
Research Group
Small-scale single assays
Tanja
Schirmeister
Institution
Jonathan
Sleeman
Institution
Peter
Kolb
University of Marburg, Department of Pharmacy
Institution
Virtual Screening
Marburg
Annika
Guse
LMU Munich, Faculty of Biology
Institution
München
Oliver
Keppler
Institution
Daniel
Merk
Institution
International
Jennifer
Keiser
Institution
Basel, Switzerland
Angelo
Frei
University of Bern, Department of Chemistry, Biology and Pharmacy
Institution
Bern, Switzerland
Johannes
Zuegg
Institution
Brisbane, Australia
Steven
Cobb
Institution
Durham, UK
Kelly
Chibale
University of Cape Town, Drug Discovery and Development Centre (H3D)
Institution
Cape Town, South Africa
Anurag
Agrawal
Cornell University, Department of Ecology and Evolutionary Biology
Institution
Ithaca, US
Johan
Neyts
KU Leuven, Rega Institute
Institution
Research Group
Small-scale single assays &
HTS Screenings
Leuven, Belgium
Luca
Grumolato
Institution
Rouen, France
Become a Life Science Screening Partner
You have become interested and want to participate as a screening partner and get compounds?
Feel free to contact us via our homepage or directly through mail or by phone. For more information, have a look under Contact.
Leave us a message!
Or choose one of these ways to contact us:
compound-platform@ioc.kit.edu
+49 721 608 23087
Karlsruhe Institute of Technology (KIT)
Institute of Biological and Chemical Systems (IBCS)
Compound Platform (ComPlat)
Hermann-von-Helmholtz-Platz 1
Building 319, room 405-443
76344 Eggenstein-Leopoldshafen
Germany
